Moducare® is a new herbal food supplement to Nutri Health.

There is incredible information regarding the formulation used in Moducare® – a clinically proven ratio of ingredients, that we wanted to share with you.

Read the report below to see if Moducare® resonates with you.

REPORT:

MODUCARE® – The Clinically Proven Ratio for Your Health Care

There is something vital about Moducare®, and in order to understand that, the following report has been compiled for your convenience.

All of the information has been taken directly from Moducare.com as the founding company of Moducare®.

Because many of the studies and reports have taken place in either South Africa or America, you may notice spelling accordingly. This has not been altered to maintain integrity.

CONTENTS:

The Story Behind Moducare®

Monograph by Dr. Karl H. Pegel

The Studies

Why Take Moducare®

What Health Professionals Say About Moducare

THE STORY BEHIND MODUCARE®

R W Liebenberg, the originator of Moducare®, grew up in a South African community which was far removed from orthodox medical care. Instead, folk remedies based on plants and herbs were used to treat whatever ailed the family.

In 1958 Mr Liebenberg witnessed the dramatic recovery of an old man from a possibly fatal illness after he was treated with a South African herbal extract.

That event finally convinced him that certain plants contained a very important active elixir, which had not yet been discovered by man. It also prompted him to embark on research which was to continue for the next forty years.

In 1968, after ten years of private research when Mr R W Liebenberg treated family and friends, he discovered that the active part of the African folk medicinal herb was a fatty substance now known as Sterols. Essential Sterolin Products (ESP) was founded to continue research on a formal basis.

Prof. Karl Pegel of the University of Natal, in Durban and his assistant were the first scientists sponsored to work for ESP. Their goal was to isolate the elusive, active compound in the plant that was responsible for the remarkable cure witnessed ten years previously.

Prof. Pegel and his team were able to extract a fatty substance which was identified as Sitosterol by the South African Council for Scientific and Industrial Research (CSIR).

Sitosterol had been identified as early as 1922 and was used in large doses to block the absorption of dietary cholesterol. As well as the Sterol they also discovered the Sterolin.

The research team proceeded to develop a product that contained sterols and sterolins in the same ratio as found in the original herbal extract.

Their work led to the release in 1974 of a patented remedy for Benign Prostatic Hypertrophy (BPH). ESP exported this product to Germany, where it has been prescribed to hundreds of thousands of BPH patients over the past 25 years.

The research team then went on to investigate the immune modulating properties of sterols and sterolins. The research was published in international scientific journals and eventually resulted in the development of a patented product called Moducare®.

Today research still continues, driven by the conviction that the human immune system holds the key to overall health. The success of ongoing clinical trials confirms the faith that the combination of plant sterols and sterolins found in Moducare® is extremely valuable in the management of many diseases.

What has been discovered so far is that Moducare® can be used to maintain the health of the prostate gland as well as normalise the function of the immune system.

MONOGRAPH by Dr. Karl H. Pegel

Moducare® is a mixture of sitosterol* (BSS) and its glucoside sitosterolin (BSSG) in a 100:1 ratio.

This formulation was originally marketed in 1974 in Germany, after its beneficial effect in the treatment of Benign Prostate Hypertrophy (BPH) had been established. Two years later, the same BSS/BSSG mixture was marketed in a product for Rheumatoid Arthritis.

In 1989, Professor Patrick Bouic and his colleagues at the Medical School of the University of Stellenbosch, Capetown, South Africa discovered that both sitosterol and sitosterolin have an immune modulating effect. Their findings which were published in the’ International Journal of Immunopharmacology’ 1996, 18, 693-700, eventually resulted in the patented product called Moducare®.

Moducare® taken orally at 3 capsules per day (each capsule contains 20.2 mg sterols/sterolins) restores weakened or reduced T cell activity in a balanced proportion of TH1 and TH2 cells. This enables the immune system to effectively counteract viral diseases (common cold, hepatitis, HIV, etc.) and various microbial diseases (tuberculosis, etc.). Moducare® also corrects a variety of autoimmune conditions (e.g. rheumatoid arthritis) usually arising from an excess secretion of inflammatory factors. However, Moducare® is not a drug: it does not interfere with any metabolic processes of either the patient or an infecting agent but it is rather a catalyst or messenger initiating a correction of existing immune system imbalances or maintaining adequate existing balances. It thereby helps an individual to maintain good health or fight a disease effectively. The use of Moducare® is ideal in conjunction with drug treatments that tend to disturb the TH1:TH2 balance or where a disease results in a TH1:TH2 imbalance which a drug cannot correct.

*sitosterol: This compound is usually described in the literature as ß-sitosterol or beta-sitosterol. The chemical name is often shortened to “sterol”.

Dr. Karl H. Pegel, CChem, FRSC
Associate Professor (Retired), School of Pure and Applied Chemistry University of Natal, Durban, South Africa

THE STUDIES:

Sterols / Sterolins for the Immune System

Reference: Bouic PJD. Sterols and sterolins: new drugs for the immune system? Drug Discovery Today 2002; 7:775-78. Clinical studies on sterols/sterolins

Tuberculosis (TB)
In a double-blind controlled study, the use of sterols/sterolins as adjunctive therapy helped TB patients recover faster, gain more weight, and exhibit less inflammation than those taking a placebo.

Marathon Runners and Immunosuppression
In this double-blind controlled trial, marathon runners who utilized the unique sterol/sterolin mixture did not exhibit any of the typical post-event immuno-suppression (e.g. neutrophilia, leucocytosis, lymphopaenia) seen in the placebo group. Moreover, those supplementing with plant sterols/sterolins were able to inhibit the inversion of CD4:CD8 ratios thereby blunting the temporary immunosuppresive effect of the race. In addition, the cortisol/DHEA-s ratio was maintained to that of pre-event levels in runners employing the BSS:BSSG mixture.

HIV Infection
In an open label study, HIV positive patients with CD4 cell counts above 500 cells/µl blood and who were not using anti-retroviral drug therapy showed stable CD4 cells counts and a decrease in their plasma viral loads after employing the BSS:BSSG mixture for up to 40 months. This group of patients maintained a predominantly TH1 profile indicating that their cell mediated immunity response accounted for both their viral control and prevention of CD4 cell loss.

Rheumatoid Arthritis

In a recent controlled trial, patients with rheumatoid arthritis (RA) had a significant reduction in their disease activity (according to American College of Rheumatology criteria) when employing the sterol/sterolin mixture.

Although both the treatment group and a placebo group in this study employed anti-inflammatory (e.g. diclofenac) and analgesic (e.g. paracetamol) medications, those patients using the plant sterol/sterolin mixture had a 48% response to the treatment compared to only 21% in the placebo group. Moreover, patients in the active group utilized fewer prescription medications suggesting that their quality of life was better. Plant sterols/sterolins, the authors note, may work similarly to the product Flemun from the German Company Intermuti Pharma which decreases cyclooxygenase and lipoxygenase activity in vivo and in vitro.

Allergic Rhinitis/Sinusitis
Those suffering with allergic conditions exhibit a predominantly TH2 profile which implies more inflammatory IL-4 secretion and hence greater release of IgE. In testing this hypothesis, 24 individuals with allergic rhinitis/sinusitis were given the sterol/sterolin mixture over a 12-week period and found to have significant reductions in their objective- (e.g. reduced rhinorrea, post-nasal drip, nasal turbinate hypertrophy, IgE levels) and subjective clinical symptoms.

Conclusion: Although the ability to control symptoms and the inflammation arising from a disordered immune system has been the mainstay of modern medical therapy, we stand on the brink of new knowledge that certain CD4 cell subsets and their soluble messengers can have a significant impact on the course of chronic disease.

While there are numerous natural products that contain phytosterols such as Gingko and Cat’s claw, it is only the 100:1 standardized mixture of plant sterols to sterolins that has been found to be optimal in balancing the delicate TH1:TH2 ratio at relatively low concentrations. Sterols and sterolins may then usher in a new era of treatment in which we try to repair the underlying abnormality rather than suppress the symptoms of disease.

Rheumatoid Arthritis (RA)

Reference: Louw,I, et al. A pilot study of the clinical effects of a mixture of beta-sitosterol and beta-sitosterol glucoside in active rheumatoid arthritis (RA). Am J Clin Nutr 2002; 75(2), 351S [Abstract 40].

Study: In a controlled trial, 18 patients were randomised to receive either 20mg BSS/0.2mg BSSG capsules (Moducare®) or placebo three times a day for 24 weeks. All patients had active RA as defined by American College of Rheumatology (ACR) criteria.

Patients in both the treatment and placebo groups used anti-inflammatory and analgesic medications for the duration of the study. No new therapies could be initiated during the study. Patient response was assessed in terms of ACR response criteria (>20% improvement).

Results: In the group receiving the BSS:BSSG mixture, statistically significant changes were noted in the mean tender joint count (85% ACR response); patient’s assessment of pain (28% response); patient’s global assessment of disease activity (33% response); physician’s global assessment of pain (47%) and the MHAQ decreased (47% response). The ESR also decreased significantly (56% response). The placebo group had no significant improvement using the ACR criteria.

Clinical Summary: Due to the potent anti-inflammatory properties of Moducare®, patients with RA may benefit from the addition of this phytosterol mixture to current management strategies.

Benign Prostatic Hyperplasia (BPH)

Reference: Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of ß-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995; 345(8964):1529-32.

Study: In this double-blind clinical trial, 200 male patients (average age 65 years) with symptoms of benign prostatic hypertrophy, were randomized to receive 20 mg ß-sitosterol plus 0.2 mg ß-sitosterol glucoside or placebo three times a day for 6 months. The product employed in the trial was Harzol™ (distributed by Hoyer GmbH and Co, Germany) with each capsule containing 10 mg ß-sitosterol and 0.1 mg ß-sitosterol glucoside. Primary assessment of the study’s outcomes was performed using a modified Boyarsky scale at monthly intervals. Secondary outcomes including International Prostate Symptom Score (IPSS), urine flow, residual urine volume, and other parameters of urinary flow plus prostate size were measured at 3 and 6 months. Laboratory values such as PSA, complete blood cell counts and a urine culture were performed at baseline and the conclusion of the study.

Results: Those patients employing ß-sitosterol and its glucoside had a significant reduction in their Boyarsky scores with an average decrease of 6.7 points compared to only 2.1 points in the placebo group after 6 months of therapy. IPSS scores also decreased in a similar fashion with average reductions of 7.4 and 2.1 points in the active and placebo groups respectively. This reduction in Boyarsky and IPSS scores were paralleled by the changes in urinary flow characteristics. For example, those patients employing Harzol™ not only had an increase in peak urinary flow from 9.9 to 15.2 ml/s but also experienced a reduction in mean residual urinary volume from 65.8 to 30.4 ml/s after 180 days of treatment. In addition, average voiding time decreased by 15.5 seconds in those utilizing Harzol™ compared to 2.8 seconds in the placebo group. Prostate volume was not affected in either group.

Clinical Summary: Both the Harzol™ and Moducare® products have their origins with the company Essential Sterolin Products in Midrand, South Africa. The Harzol™ product employed in this study by Berges et al contains the same active ingredients as found in Moducare®, namely ß-sitosterol and ß-sitosterol glucoside in a 100:1 ratio. However, unlike Harzol™, each Moducare® capsule contains twice as much of the active ingredient (e.g. 20 mg ß-sitosterol and 0.2 mg ß-sitosterol glucoside). Thus patients with BPH may experience a significant change in their symptoms (e.g. better urinary flow, less urinary retention, and fewer night time awakenings) by employing the product Moducare® at a dose of one capsule three times a day for at least 6 months.

WHY TAKE MODUCARE®

The sterols and sterolins in Moducare® have clearly been shown to work in helping to maintain the body’s immune system in balance when taken on a long term basis.

Supplementation with sterols and sterolins helps preserve an optimum balance of these micronutrient,s and provides a natural means of supporting the body’s defence system to keep up with the demands of modern life.

Sterols & sterolins, collectively referred to as Phytosterols, are plant compounds, found in the membranes of all plants – chemically similar to cholesterol but different in biological function.

Only plants can synthesise these phytosterols, regarded as essential micronutrients, as both humans and animals need to obtain them from their diets.

Although sterols & sterolins are found naturally in fruits, vegetables, seeds and nuts, it is often difficult to obtain optimum amounts through diet alone. What’s more, it is also difficult for your body to absorb optimum amounts of sterols and sterolins from food – as they are bound to the fibres in plants.

Furthermore, common food preparation methods such as cooking, processing and preserving often destroy or completely remove the valuable plant nutrients from your diet.

Supplementing with Moducare® can therefore play supportive role in safeguarding your nutritional intake.

WHAT HEALTH PROFESSIONALS SAY ABOUT MODUCARE:

Professor Patrick JD Bouic, PhD trained at the University of Natal, Durban, where he earned a degree in Biological Sciences. He matriculated to the University of Claude Bernard in Lyon, France, where he received his doctoral degree in Immunology. Currently, he is the Head of Immunology at Stellenbosch University in Cape Town, South Africa, where he is also a tenured professor in the Department of Medical Microbiology. For more than a decade, Professor Bouic has been researching the effects of plant sterols and sterolins on human health. He has devoted much of his time to the study of tuberculosis and HIV. His research on the power of sterols and sterolins to stop T-cell counts from dropping in HIV-infected individuals may well change the way immunosuppressed patients will be treated in the future.

Professor Bouic is a well-known and respected researcher in the field of immunology and has published many scientific papers. He co-authored The Immune System Cure with Lorna Vanderhaeghe in 1999.

Dr. Bouic advocates a healthy lifestyle and regards sterols and sterolins as “an insurance policy against illness. During the fifteen years I have been taking Moducare®, I have not had a single cold or flu.”

Dr. Jim LaValle is a licensed pharmacist, certified clinical nutritionist and Doctor of Naturopathic Medicine. He is in a professional consulting practice at the Living Longer Institute where he has specialized in natural therapeutics for over 18 years.

Jim is president of Natural Health Resources, Inc., a company which provides technology, educational initiatives and consulting for natural medicine. He is on the scientific advisory board for the Dietary Supplement Education Alliance and is a board member for the Dietary Supplement Information Bureau. Jim is a frequent writer for many trade publications, speaker at industry events and a guest on radio and TV. Most recently, Jim can be seen on Body Shaping, the #1 rated fitness show on ESPN where he is the featured nutrition expert. Jim has published seven books including, Smart Medicine for Healthier Living, The COX 2 Connection and Cracking the Metabolic Code. Jim is an adjunct professor in the College of Pharmacy at University of Cincinnati. He was named one of the “50 Most Influential Pharmacists of 1998″ by American Druggist magazine.

“Stress has become woven into the fabric of our culture. Recent scientific research has linked the metabolic effects of stress with a wide range of conditions and symptoms. Chronic stress can put your body’s primary defense system out of balance. If you are looking for added support for your immune system, consider Moducare®.”

Lorna Vanderhaeghe, B.Sc. is a dedicated health journalist and author committed to healthy, natural living. “Many people are becoming disenchanted with conventional medicine’s drugs and the cut and burn approach to disease,“ says Lorna. “Illnesses that are caused by inadequate nutrition, too much stress, and environmental toxins do not respond well to prescription drug therapies.” Lorna has spent the last twenty years of her career reviewing research papers from around the world, writing, and educating the public about the merits of nutritional, natural treatments to gain optimum health and wellness. She is publisher of the Healthy Immunity newsletter and website, associate editor for Alive magazine in Canada and for Total Health, a U.S. magazine committed to healthy, natural living. Lorna is the co-author, with Dr. Patrick Bouic, of the book The Immune System Cure (1999) now published in six countries and translated into French, Dutch and German.

Lorna is also the author of Healthy Immunity: Scientifically Proven Natural Treatments for Conditions from A-Z (2001), No More HRT: Menopause Treat The Cause (2002), and Healthy Fats for Life (2003). People from around the world seek Lorna’s advice and she has become a much sought after lecturer and media guest.

“Over the last 5 years I have received thousands of letters, phone calls and emails from those who have regained their health using Moducare®. I believe Moducare® will change the way we treat disease in the future through its mechanism of correcting and balancing the immune system and controlling inflammation.”

Dr. James Rouse is a naturopathic physician, entrepreneur and coach to executives, athletes, physicians, families and peak performers nationwide. He is a leading expert in the field of lifestyle medicine and performance training. James is also a parent, businessman, and a sponsored Ironman triathlete. In addition, he is the founder and chairman of Envitalment, Inc., a wellness and performance coaching, training and consulting company. Dr. Rouse maintains a private naturopathic medical practice in Denver, Colorado. These two disciplines, combined with his own personal commitment to be a life-long learner and student of successful living, enable James to understand and teach what creates a happy, fulfilled and balanced life. He is also the creator and spokesperson on TV, Denver’s KUSA Optimum Wellness, a program seen daily by millions, educating and encouraging Coloradoans to take charge of their health.

“I have successfully used Moducare®, not only personally but in my practice, prescribing it to patients who were suffering from numerous conditions resulting from a compromised immune system: rheumatoid arthritis, lupus, irritable bowel syndrome, asthma, allergies, colds and flu and a variety of other inflammatory conditions. All improved significantly. As a clinician, coach and athlete, I have come to depend on and fully trust the results I get with Moducare® and its scientifically proven immune-optimizing properties.”

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